1-(2-Hydroxyethyl)piperazine → HCID 71087171, compound

Participants

Reaction Conditions

Reaction Steps

2-(Butyloxy)-9-(3-chloropropyl)-8-(methyloxy)-9H-purin-6-amine (for example, as prepared for Intermediate 39) (80 mg, 0.255 mmol), DIPEA (0.134 mL, 0.765 mmol) and 2-(1-piperazinyl)ethanol (commercially available, for example, from Aldrich) (133 mg, 1.020 mmol) was heated in acetonitrile (2 mL) in a test-tube in a Radley greenhouse. The reaction was heated at 70° C. for 28 hours then allowed to cool and evaporated in vacuo. Aqueous sodium bicarbonate was added and the mixture was extracted several times with chloroform, the chloroform being filtered through a hydrophobic frit separator. The solvent was removed to give a brown gum (171 mg) which was purified on MDAP (method A). The fractions were evaporated in vacuo and the residue worked up with an aqueous sodium bicarbonate/chloroform extraction as before and the solvent removed to give the title compound as a colourless oil (80 mg).

Provenance & Evidence