HCID 69670019, compound → HCID 69670217, compound

HRID 2038208Notes

Reaction equation

HRID 2038208 reaction equation
[CH:1]([CH:4]1[CH2:9][CH2:8][CH:7]([CH3:10])[CH2:6][CH:5]1[N:11]1[CH2:15][CH:14]([C:16]([N:18]2[CH2:22]C[CH2:20][CH2:19]2)=[O:17])[CH2:13][C:12]1=[O:23])([CH3:3])[CH3:2].C(C1CCC(C)CC1N1C(=O)CC(C(O)=O)C1)(C)C>>[N:18]1([C:16]([CH:14]2[CH2:15][N:11]([CH:5]3[CH2:6][CH:7]([CH3:10])[CH2:8][CH2:9][CH:4]3[CH:1]([CH3:2])[CH3:3])[C:12](=[O:23])[CH2:13]2)=[O:17])[CH2:19][CH2:20][CH2:22]1

Participants

3

Reactant 2

HCID 69670019HCID 69670019, compoundHCID 69670118HCID 69670118, compound

Product 1

HCID 69670217HCID 69670217, compound

Procedure

1-(2-Isopropyl-5-methyl-cyclohexyl)-4-(pyrrolidine-1-carbonyl)-pyrrolidin-2-one was similarly prepared as described in Examples I, II, and III. 1-(2-Isopropyl-5-methyl-cyclohexyl)-5-oxo-pyrrolidine-3-carboxylic acid (obtained as in EXAMPLE II, 10 g, 37.5 mmol) was used to provide 4-(azetidine-1-carbonyl)-1-(2-isopropyl-5-methyl-cyclohexyl)-pyrrolidin-2-one (10.2 mg, 32 mmol).

Sources & evidence

ORD record
ord-481b0dff01bf4bd9b0f695521c2bf942
Source dataset
uspto-grants-2013_11
Patent number
US08575349B2

Reaction notes

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