2-tert-Butylcyclohexanone → HCID 69669983, compound

HRID 2038212Notes

Reaction equation

HRID 2038212 reaction equation
[C:1]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH:6]1[N:11]1[CH2:15][CH:14]([C:16](N2CCCC2)=[O:17])[CH2:13][C:12]1=[O:23])([CH3:4])([CH3:3])[CH3:2].C(C1CCCCC1=[O:34])(C)(C)C>>[C:1]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH:6]1[N:11]1[C:12](=[O:23])[CH2:13][CH:14]([C:16]([OH:17])=[O:34])[CH2:15]1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 1026812-tert-ButylcyclohexanoneHCID 69670058HCID 69670058, compound

Product 1

HCID 69669983HCID 69669983, compound

Procedure

1-(2-tert-Butyl-cyclohexyl)-4-(pyrrolidine-1-carbonyl)-pyrrolidin-2-one was similarly prepared as described in Examples I, II, and VI. 2-tert-Butylcyclohexanone (commercially available at Alfa Aesar GmbH & Co. KG) was used to obtain 1-(2-tert-butyl-cyclohexyl)-5-oxo-pyrrolidine-3-carboxylic acid (1 g, 3.74 mmol), which was subsequently used to provide 1-(2-tert-butyl-cyclohexyl)-4-(pyrrolidine-1-carbonyl)-pyrrolidin-2-one (1.1 g, 3.2 mmol).

Sources & evidence

ORD record
ord-d6be44e0f5a441f19dc5c1a67b1eb1d9
Source dataset
uspto-grants-2013_11
Patent number
US08575349B2

Reaction notes

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