HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 4-[hydroxy(diphenyl)methyl]-1-(tetrahydro-2H-pyran-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 3-(Bromomethyl)oxane | HCID 22617257 | — |
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| Product | 4-[hydroxy(diphenyl)methyl]-1-(tetrahydro-2H-pyran-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane bromide | HCID 68960657 | 50.8% |
Reaction Steps
Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct -4-yl(diphenyl)methanol (0.0677 g, 0.231 mmol) and 3-(bromomethyl)tetrahydro-2H-pyran (0.050 mL, 0.390 mmol) in 2 CH3CN/3CHCl3 (4.0 mL) were reacted to give the desired product (0.0508 g, 50.8%). ELMS m/z 392(M+) Rt (1.84 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575347B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-9a36152b93504f659f9a96a3e4d9de9b |
| Source note | uspto-grants-2013_11 |