HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromo-propoxy)-phenol → 4-[Hydroxy(diphenyl)methyl]-1-{3-[(2-hydroxyphenyl)oxy]propyl}-1-azoniabicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromo-propoxy)-phenol | HCID 13197597 | — |
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[Hydroxy(diphenyl)methyl]-1-{3-[(2-hydroxyphenyl)oxy]propyl}-1-azoniabicyclo[2.2.2]octane bromide | HCID 11591759 | 75% |
Reaction Steps
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct -4-yl(diphenyl)methanol (0.0505 g, 0.172 mmol) and 2-[(3-bromopropyl)oxy]phenol (0.0547 g, 0.236 mmol) in 2 CH3CN/3CHCl3 (4.0 mL) were reacted to give the desired product (0.0675 g, 75.0%). EI-MS m/z 444(M+) Rt (1.91 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575347B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-e3b8ca8ec6f247f5b93b3c3d274d84b7 |
| Source note | uspto-grants-2013_11 |