1-(3-Bromopropoxy)-3-chlorobenzene → 1-{3-[(3-Chlorophenyl)oxy]propyl}-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide

Participants

Reaction Steps

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct -4-yl(diphenyl)methanol (0.0479 g, 0.163 mmol) and 3-bromopropyl 3-chlorophenyl ether (0.0552 g, 0.221 mmol) in 2 CH3CN/3CHCl3 (4.0 mL) were reacted to give the desired product (0.0655 g, 74.4%). ELMS m/z 462(M+) Rt (2.17 min).

Provenance & Evidence