HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol → 3-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| Reactant | 3-[(3-bromopropyl)oxy]-N,N-diethylaniline | HCID 68963374 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-{[3-(Diethylamino)phenyl]oxy}propyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide | HCID 11534358 | 63% |
Reaction Steps
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct -4-yl(diphenyl)methanol (0.0257 g, 0.0876 mmol) and 3-[(3-bromopropyl)oxy]-N,N-diethylaniline (0.0314 g, 0.110 mmol) in 2 CH3CN/3CHCl3 (4.0 mL) were reacted to give the desired product (0.032.0 g, 63.0%). ELMS m/z 500(M+) Rt (1.58 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575347B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d03fb82e6f6841e5845c377ea6d57c8e |
| Source note | uspto-grants-2013_11 |