HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10879224, compound → 1-{3-[(4-Cyanophenyl)oxy]propyl}-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10879224 | HCID 10879224 | — |
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-{3-[(4-Cyanophenyl)oxy]propyl}-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide | HCID 11584609 | 76.9% |
Reaction Steps
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct -4-yl(diphenyl)methanol (0.0520 g, 0.177 mmol) and 4-[(3-bromopropyl)oxy]benzonitrile (0.156 g, 0.652 mmol) in 2 CH3CN/3CHCl3 (4.0 mL) were reacted to give the desired product (0.0726 g, 76.8%). ELMS m/z 453(M+) Rt (1.86 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575347B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-24d221c240fa4fd7ac42744bb1fcae85 |
| Source note | uspto-grants-2013_11 |