Imidazole → HCID 69257272, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of imidazole (1.0 g, 14.7 mmol), benzaldehyde diethylacetal (58.8 mmol), and p-toluenesulfonic acid (84 mg, 0.441 mmol) was heated neat at 110° C. for 1-3 days, accompanied by concurrent distillation of ethanol. After cooling, sodium carbonate (0.47 g, 4.41 mmol) was added and the crude mixture was distilled under vacuum (150-170° C./0.5 mmHg) to give N-ethoxybenzylimidazole derivatives (1-8) (15-75% yield).

Provenance & Evidence