Tetrahydrofuran → 1-{[5-Bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Participants

Reaction Steps

190 mg of the compound from Example 6A having a purity of 86% (0.49 mmol), 107 mg (0.54 mmol) of the compound from Example 20A and 380 mg (0.73 mmol) of PyBOP are provided in 2 ml of tetrahydrofuran, and 0.27 ml (1.56 mmol) of N,N-diisopropylethylamine are added at room temperature. The reaction mixture is stirred at room temperature overnight and then purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with the addition of 0.1% formic acid). 109 mg (55% of theory) of the title compound are obtained.

Provenance & Evidence