Ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate → 4-(3-Chloro-4-fluorophenyl)-5-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

HRID 2038367Notes

Reaction equation

HRID 2038367 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:22]([OH:24])=[O:23])[S:12][C:13]=2[C:14]2[CH:19]=[C:18](F)[CH:17]=[C:16]([Cl:21])[CH:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].BrC1SC(C(OCC)=O)=NC=1C1C=CC(F)=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:22]([OH:24])=[O:23])[S:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:21])[CH:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 70801639Ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylateHCID 708016444-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Product 1

HCID 708016424-(3-Chloro-4-fluorophenyl)-5-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 8A starting with the compound from Example 4A. 80.0 mg (79% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-071897bdd8c84a8eaf686d8560288fdc
Source dataset
uspto-grants-2013_11
Patent number
US08575357B2

Reaction notes

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