Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate → 5-(3-Chloro-4-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

HRID 2038369Notes

Reaction equation

HRID 2038369 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](C2N=C(C(O)=O)SC=2C2C=C(F)C=C(Cl)C=2)[CH:5]=[CH:6][C:7]=1[F:8].Br[C:26]1[S:30][C:29]([C:31]([O:33]CC)=[O:32])=[N:28][C:27]=1[C:36]1[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:26]2[S:30][C:29]([C:31]([OH:33])=[O:32])=[N:28][C:27]=2[C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 70801641Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylateHCID 708016444-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

Product 1

HCID 708017375-(3-Chloro-4-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 8A starting with the compound from Example 5A. 59.0 mg (56% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-809c5eb9504b41c6b244fde24a57d6ce
Source dataset
uspto-grants-2013_11
Patent number
US08575357B2

Reaction notes

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