HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate → 4-(3-Chlorophenyl)-5-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate | HCID 70801641 | — |
| Reactant | 4-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid | HCID 70801644 | — |
| Product | 4-(3-Chlorophenyl)-5-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid | HCID 70313677 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 8A starting with the compound from Example 5A. 556 mg of the title compound having a purity of 41% (46% of theory) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575357B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c9b54eaf49634cc1835f3ad8ab805fdd |
| Source note | uspto-grants-2013_11 |