HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate → 4-(3-Chloro-4-fluorophenyl)-5-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate | HCID 70801639 | — |
| Reactant | 4-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid | HCID 70801644 | — |
| Product | 4-(3-Chloro-4-fluorophenyl)-5-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid | HCID 70342887 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 8A starting with the compound from Example 4A. 161 mg (76% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575357B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-7e12b4c412874a4d9520abc3f9cc5ed2 |
| Source note | uspto-grants-2013_11 |