Sodium Carbonate → HCID 70313808, compound

Participants

Reaction Conditions

Reaction Steps

At room temperature, 2.2 ml of an aqueous 2M sodium carbonate solution and 30.8 mg (0.027 mmol) of tetrakis(triphenylphosphine)palladium are added to 300 mg (0.890 mmol) of the compound from Example 35A and 209 mg (1.34 mmol) of (3-chlorophenyl)boronic acid in 12 ml of DME, and the mixture is subsequently stirred at 80° C. overnight. The crude product is filtered through a short kieselguhr column and the filtrate is concentrated under reduced pressure. The residue is purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). 132 mg (37% of theory) of the title compound having a purity of 85% are obtained.

Provenance & Evidence