1-{[4-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one → 1-{[5-(3-Chloro-5-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

HRID 2038388Notes

Reaction equation

HRID 2038388 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:22]([N:24]3[CH2:28][C:27](=[O:29])[NH:26][CH2:25]3)=[O:23])[S:12][C:13]=2[C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[C:16]([Cl:21])[CH:15]=2)[CH:5]=[CH:6][C:7]=1F.ClC1C=C(C2SC(C(O)=O)=NC=2C2C=CC=C(Cl)C=2)C=C(F)C=1>>[Cl:21][C:16]1[CH:15]=[C:14]([C:13]2[S:12][C:11]([C:22]([N:24]3[CH2:28][C:27](=[O:29])[NH:26][CH2:25]3)=[O:23])=[N:10][C:9]=2[C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH:19]=[C:18]([F:20])[CH:17]=1

Participants

3

Reactant 2

HCID 509428481-{[4-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-oneHCID 708016405-(3-Chloro-5-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid

Product 1

HCID 509429141-{[5-(3-Chloro-5-fluorophenyl)-4-(3-chlorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 1 starting with the compound from Example 10A. 40.0 mg (41% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-80df5943aa8c473ab6c87c9c676cf547
Source dataset
uspto-grants-2013_11
Patent number
US08575357B2

Reaction notes

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