Tetrahydrofuran → HCID 50942990, compound

Participants

Reaction Steps

45.0 mg (0.119 mmol) of the compound from Example 30A having a purity of 84%, 26.3 mg (0.131) of the compound from Example 20A and 93.2 mg (0.179 mmol) of PyBOP are provided in 4.8 ml of tetrahydrofuran, and 67 μl (0.382 mmol) of N,N-diisopropylethylamine are added at room temperature. The reaction solution is stirred at room temperature overnight, diluted with dichloromethane and subsequently washed with a 1N aqueous hydrogen chloride solution. The organic phase is dried over magnesium sulfate, filtered and concentrated under reduced pressure, and the crude product is then purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient). 25.0 mg (56% of theory) of the title compound are obtained.

Provenance & Evidence