HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2038416Generated: October 31, 2026
Triethylamine → (3S)-N-{1-[(3-Fluoro-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine
https://huagongshe.com/reaction/2038416
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Fluoro-5-phenyl-benzo[b]thiophene-2-carbonyl chloride | HCID 59625725 | — |
| Reactant | (S)-(3-(Azetidin-3-ylamino)pyrrolidin-1-yl)(phenyl)methanone | HCID 67288563 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3S)-N-{1-[(3-Fluoro-5-phenyl-1-benzothiophen-2-yl)carbonyl]azetidin-3-yl}-1-(phenylcarbonyl)pyrrolidin-3-amine | HCID 67287028 | 26.7% |
Reaction Steps
To a solution of compound 5e (42.7 mg, 0.131 mmol) and Et3N (0.07 mL, 0.5 mmol) in CH2Cl2 (2 mL) at 0° C. was slowly added a solution of compound 13e (36.3 mg, 0.125 mmol) in CH2Cl2 (1 mL). The reaction was stirred at 0° C. for 2 h, diluted with CH2Cl2, and washed with aqueous NaHCO3. The organic layer was dried over Na2SO4 and concentrated. The residue was purified by flash column chromatography (silica gel, % MeOH/EtOAc) to give compound Cpd 173 (16.7 mg). MS m/z (M+H+) 500.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08575363B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-f8d1a1478f034e0cb76e0f036b649dce |
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| Source note | uspto-grants-2013_11 |
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