HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(2,2,2-Trifluoroethoxy)ethyl p-toluenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 2-(2,2,2-Trifluoroethoxy)ethan-1-ol | HCID 255854 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-(2,2,2-Trifluoroethoxy)ethyl p-toluenesulfonate | HCID 22033295 | — |
Reaction Steps
2-(2,2,2-trifluoroethoxy)ethanol (intermediate BR) (12.7 g) was dissolved in anhydrous pyridine, then TsCl (1.3 eq) was added, and the mixture was stirred at room temperature for 16 h, after which TLC showed the reaction was complete. Then the mixture was poured into water, extracted with EA, washed with water and brine, and dried with anhydrous Na2SO4. The solvent was removed and the residue purified by column chromatography to obtain intermediate BS (0.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575321B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6e7632544403493788a3726aefa282e6 |
| Source note | uspto-grants-2013_11 |