HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(Cyclohex-2-enyloxy)ethyl 4-methylbenzenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | 2-(Cyclohex-2-enyloxy)ethanol | HCID 11286526 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-(Cyclohex-2-enyloxy)ethyl 4-methylbenzenesulfonate | HCID 57684685 | — |
Reaction Steps
To 2-(cyclohex-2-enyloxy)ethanol (intermediate BU) (0.3 g) in anhydrous pyridine was added TsCl (1.3 eq). The mixture was stirred at room temperature for 16 h, after which TLC showed the reaction was complete. The mixture was poured into water, extracted with EA, washed with water and brine, and dried with anhydrous Na2SO4. Solvent was removed and the residue purified by column chromatography to obtain intermediate BV (0.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575321B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-0a472b75bcb343328be5334ac069e437 |
| Source note | uspto-grants-2013_11 |