HCID 59547335, compound → HCID 59547341, compound

Participants

Reaction Steps

Palladium (10%) on carbon (100 mg) was wetted with MeOH (2.5 mL) and added to (5S,8S)-tert-butyl 7-((S)-2-(benzyloxycarbonylamino)-3,3-dimethylbutanoyl)-2-oxo-3-phenyl-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate (E1) (323 mg, 411 mot, 1 eq.). The reaction was hydrogenated at 50 psi overnight at room temp., then filtered and concentrated to give (5S,8S)-tert-butyl 7-((S)-2-amino-3,3-dimethylbutanoyl)-2-oxo-3-phenyl-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate (F1) in quantitative yield. LC MS+: 432.39 at 1.94 min (10-90%, 3-5 min, Formic Acid).

Provenance & Evidence