(3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide → HCID 59547311, compound

Participants

Reaction Steps

Following the same procedure as Example 1 step 9 using (5R,8S)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-2-oxo-3-phenyl-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylic acid (49 mg, 98 μmol) and (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide (31 mg, 137 μmol, 1.4 eq.) gave 20 mg (30 μmol) of (5R,8S)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-2-oxo-3-phenyl-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxamide (G2). LC MS+/−: 668.56/666.64 at 3.24 min (10-90%, 3-5 min, Formic Acid).

Provenance & Evidence