HRID2038561

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7928

Benzene, 1-bromo-3-chloro-

C6H4BrCl

结构：CC(C)(C)OC(=O)[C@@H]1CC2(CNC(=O)O2)CN1C(=O)OC(C)(C)C

HCID59547287

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)[C@@H]1C[C@@]2(CN(c3cccc(Cl)c3)C(=O)O2)CN1C(=O)OC(C)(C)C

HCID59547291

未命名化合物

收率 36.1%

PROCEDURE

实验过程

Following the same procedure as Example 1 step 3 using (8S)-di-tert-butyl 2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-7,8-dicarboxylate (8S)-di-tert-butyl 2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-7,8-dicarboxylate (B1) (224 mg, 0.654 mmol) and 3-chloro bromobenzene (230 μL, 1.962 mmol, 3 eq.) gave 107 mg (0.236 mmol) of (5S,8S)-di-tert-butyl 3-(3-chlorophenyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-7,8-dicarboxylate (A3). 1H NMR (300 MHz, DMSO) 7.68 (m, 1H), 7.55-7.38 (m, 2H), 7.2 (m, 1H), 4.23-4.05 (m, 3H), 3.8-3.7 (m, 1H), 3.5 (m, 1H), 2.7-2.6 (m, 1H), 2.25-2.1 (m, 1H), 1.4 (m, 18H).