HCID 59547300, compound → HCID 59547331, compound

Participants

Reaction Steps

Following the procedure from Example 1 step G using (5R,8S)-tert-butyl-3-(3-chlorophenyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate (B4) (20 mg, 54 μmol, 1 eq.) and (S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoic acid (16 mg, 63 μmol, 1.2 eq.) gave 16 mg (27 μmol) of (5R,8S)-tert-butyl-3-(3-chlorophenyl)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate (C4). LC MS+/−: 590.31/589.47 at 3.95 min (10-90%, 3-5 min, Formic Acid).

Provenance & Evidence