(3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide → HCID 59547324, compound

Participants

Reaction Steps

Following the procedure from Example 1 step I using (5R,8S)-3-(3-chlorophenyl)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylic acid (D4) (12 mg, 22 μmol) and (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide (7.3 mg, 33 μmol) gave 10 mg (14 μmol) of (5R,8S)-3-(3-chlorophenyl)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxamide (E4). LC MS+/−: 702.54/700.74 at 3.68 min (10-90%, 3-5 min, Formic Acid).

Provenance & Evidence