(3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide → HCID 59547356, compound

Participants

Reaction Steps

Following the procedure from Example 1 step 1 using (5S,8S)-3-(3-chlorophenyl)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylic acid (D5) (23 mg, 43 μmol) and (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide (15 mg, 65 μmol) gave 10 mg (14 μmol) of (5S,8S)-3-(3-chlorophenyl)-7-((S)-2-(2-cyclohexylacetamido)-3,3-dimethylbutanoyl)-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxamide (E5). LC MS+/−: 702.54/700.62 at 3.63 min (10-90%, 3-5 min, Formic Acid).

Provenance & Evidence