Ethanol → Ethyl (S)-2-amino-3-(4-aminophenyl)propanoate

Participants

Reaction Conditions

Reaction Steps

About 40 g of dried L-4-amino phenylalanine was mixed with 1000 mL of ethanol. The reaction mass was dehydrated by distilling out about 20% of the ethanol added. To the dried reaction mixture about 300 g of dry hydrochloric acid gas was purged in. The reaction mass was warmed to about 80° C. and the reaction was promoted by removing condensation (water formed in the reaction) by distillation. The progress of the reaction was monitored by HPLC analysis. Upon completion of the esterification reaction, the reaction mass was neutralized with sodium bicarbonate and the precipitated inorganic salt was removed, isolated, washed with ethanol, and the filtrate was collected. The filtrate was concentrated by distillation and dehydrated to a thick mass. (the weight of reaction mass residue was 41 g; its purity 98%.)

Provenance & Evidence