Cinacalcet → Cinacalcet Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Cinacalcet (0.25 moles, 91 gms) was taken in a reaction vessel and IPA/HCl (85 ml) was added dropwise and stirred for about 15 minutes. The solvent was distilled at 50-55° C. under high vacuum to obtain a residue. The residue was suspended in ethyl acetate (516 ml) and heated to reflux temperature until a clear solution was obtained and the solution stirred for about 30 minutes. The solution was cooled to 0-5° C. and stirred to obtain a solid. The solid was washed with ethyl acetate (2×85 ml) and dried at 55-60° C. to obtain the title compound (70 gms, Yield 70%, HPLC purity=98.5%).

Provenance & Evidence