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HRID2038667

反应详情

EQUATION

反应方程式

HRID 2038667 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1ccsn1
HCID559224

1,2-Thiazole-3-carboxylic acid

C4H3NO2S

结构：Br.Br.Br.CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCNCC4)n[nH]c2c1
HCID136333962

未命名化合物

PRODUCTS

生成物

1
结构：CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(C(=O)c3ccsn3)CC4)n[nH]c2c1
HCID136263957

未命名化合物

收率 25.6%

PROCEDURE

实验过程

The title compound was prepared from isothiazole-3-carboxylic acid (11 mg, 85 μmol) and 5-ethyl-2-fluoro-4-[3-(1,4,5,6,7,8-hexahydro-imidazo[4,5-d]azepin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt (Preparation 32, 50 mg, 80 μmol) using the method of Example 8. The crude material was purified by HPLC Method B to afford 10.3 mg of the title compound.

WORKUP

后处理

  1. customThe crude material was purified by HPLC Method B