HRID2038681

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2763980

6-(Piperidin-1-yl)pyridine-3-carbaldehyde

C11H14N2O

结构：Br.Br.Br.CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCNC4)n[nH]c2c1

HCID178419240

未命名化合物

PRODUCTS

生成物

结构：CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CCN(Cc3ccc(N5CCCCC5)nc3)C4)n[nH]c2c1

HCID178436908

未命名化合物

收率 30.3%

PROCEDURE

实验过程

The title compound was prepared from 3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carbaldehyde (38 mg, 198 μmol) and 5-ethyl-2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-phenol trihydrobromide salt (Preparation 25, 50 mg, 132 μmol) using the method of Example 22. The crude material was purified by HPLC Method A to afford 22.1 mg of the title compound.

WORKUP

后处理

customThe crude material was purified by HPLC Method A

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ebd74f045bb4cbcab675309693bf8c3
来源数据集: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08575336B2
来源说明: uspto-grants-2013_11

反应 SMILES

[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH:13]=O)=[CH:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br.Br.Br.[CH2:18]([C:20]1[C:21]([C:28]2[CH:36]=[C:35]3[C:31]([C:32]([C:37]4[NH:38][C:39]5[CH2:44][CH2:43][NH:42][CH2:41][C:40]=5[N:45]=4)=[N:33][NH:34]3)=[CH:30][CH:29]=2)=[CH:22][C:23]([F:27])=[C:24]([OH:26])[CH:25]=1)[CH3:19]>>[CH2:18]([C:20]1[C:21]([C:28]2[CH:36]=[C:35]3[C:31]([C:32]([C:37]4[NH:38][C:39]5[CH2:44][CH2:43][N:42]([CH2:13][C:10]6[CH:11]=[CH:12][C:7]([N:1]7[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]7)=[N:8][CH:9]=6)[CH2:41][C:40]=5[N:45]=4)=[N:33][NH:34]3)=[CH:30][CH:29]=2)=[CH:22][C:23]([F:27])=[C:24]([OH:26])[CH:25]=1)[CH3:19]