HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoic Acid → HCID 178464444, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoic Acid | HCID 9973 | — |
| Reactant | 2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-5-(2,2,2-trifluoro-ethyl)-phenol | HCID 178516038 | — |
| Product | HCID 178464444 | HCID 178464444 | 63.3% |
Reaction Steps
The title compound was prepared from 4-fluoro-benzoic acid (24 mg, 168 μmol) and 2-fluoro-4-[3-(4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl]-5-(2,2,2-trifluoro-ethyl)-phenol (Preparation 39, 100 mg, 168 μmol) using the method of Example 8. The crude material was purified by HPLC Method A to afford 33.3 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575336B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d3ca76b502b14fc5bd688c04ff2c9eaf |
| Source note | uspto-grants-2013_11 |