Hydrochloric Acid → HCID 67515208, compound

Participants

Reaction Steps

To the solution of {1-[5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester (80 mg, 0.23 mmol) in CH2Cl2 (10 mL) was added 4M HCl (2 mL, 8 mmol). After stirring overnight, more 4M HCl (0.1 mL, 0.4 mmol) was added. After a total of 42 h, diethyl ether (10 mL) was added to the reaction mixture and stirring was continued for 10 min. The reaction suspension was filtered and the solid was washed with ether (10 mL) to afford 1-[5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-pyridin-2-yl]-cyclopropylamine HCl salt (40 mg) as a white solid.

Provenance & Evidence