HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[5-(1H-Pyrazol-4-yl)-pyridin-2-yl]-cyclobutylamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | {1-[5-(1H-pyrazol-4-yl)-pyridin-2-yl]-cyclobutyl}-carbamic acid tert-butyl ester | HCID 68379199 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[5-(1H-Pyrazol-4-yl)-pyridin-2-yl]-cyclobutylamine dihydrochloride | HCID 68379039 | — |
Reaction Steps
To a solution of {1-[5-(1H-pyrazol-4-yl)-pyridin-2-yl]-cyclobutyl}-carbamic acid tert-butyl ester (300 mg, 0.96 mmol) in CH2Cl2 (5 mL) was added TFA (0.37 mL, 4.8 mmol). After 15 h, 4M HCl in dioxane (1.2 mL, 4.8 mmol) was added. After 1 h, the reaction was concentrated in-vacuo to yield 303 mg of the title compound, m/z 215.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575360B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ab8fb77e4c8e4faca721c2c16f191b1d |
| Source note | uspto-grants-2013_11 |