Hydrochloric Acid → HCID 68378913, compound

Participants

Reaction Steps

{(1S,2R)-2-hydroxy-1-[(R)-1-(6′-methyl-[3,3′]bipyridinyl-6-yl)-ethylcarbamoyl]-propyl}-carbamic acid tert-butyl ester (0.23 g, 0.45 mmol) was dissolved in CH2Cl2 (2 mL) and 4M HCl in dioxane (2 mL, 4 mmol) was added. After 1.5 hours, the volatiles were removed under a stream of N2 to give 300 mg of (2S,3R)-2-amino-3-hydroxy-N-[(R)-1-(6′-methyl-[3,3′]bipyridinyl-6-yl)-ethyl]-butyramide trihydrochloride salt as a tan powder, m/z 315.7 [M+H]+.

Provenance & Evidence