Triphenylphosphine → 3-(4-Ethoxy-2,3-difluorophenyl)propyltriphenylphosphonium bromide

Participants

Reaction Conditions

Reaction Steps

3-(4-Ethoxy-2,3-difluorophenyl)bromopropane (s22) (11.5 g), toluene (100 ml) and triphenylphosphine (21.6 g) were placed in a reaction vessel under an atmosphere of nitrogen, and the mixture was heated to reflux for 5 hours. After the reaction mixture had been cooled to 25° C., the deposits were filtered, and the unreacted material was removed by washing with toluene three times. The resulting colorless solids were dried to give 3-(4-ethoxy-2,3-difluorophenyl)propyltriphenylphosphonium bromide (s23) (17.6 g). The yield based on the compound (s22) was 78.9%.

Provenance & Evidence