Triethylamine → HCID 44241828, compound

Participants

Reaction Steps

32.00 g (246 mmol) of 2-propenyl 2-hydroxypropionate and 31.3 g (310 mmol) of triethylamine were dissolved in 150 g of toluene (solvent), and 35.6 g (310 mmol) of methanesulfonyl chloride was dropwise added thereto at 10° C., taking 20 minutes. These were reacted at room temperature for 1 hour, the reaction liquid was washed twice with water, then the organic layer was separated and concentrated. The concentrate was purified through silica gel column chromatography, and from the fraction taken with hexane/ethyl acetate=5/1, 27 g (yield 53%) of 2-propenyl 2-(methanesulfonyloxy)propionate was obtained.

Provenance & Evidence