HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 9-(9H-carbazol-3-yl)-pyrido[2,3-b]indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 9-(9-Tosyl-carbazol-3-yl)-pyrido[2,3-b]indole | HCID 70815224 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 9-(9H-carbazol-3-yl)-pyrido[2,3-b]indole | HCID 70815101 | 70.9% |
Reaction Steps
A mixture solution of 9-(9-tosyl-carbazol-3-yl)-pyrido[2,3-b]indole (9.9 g, 20.30 mmol) and NaOH (8.12 g, 203 mmol) in THF (100 mL), ethanol (50 mL) and water (50 mL) was refluxed over weekend. After cooling to room temperature, the white solid was obtained by filtration, and washed successively with water, ethanol, DCM and ethanol to yield the 9-(9H-carbazol-3-yl)-9H-pyrido[2,3-b]indole (4.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580399B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-efa52f0cb2d54664bb821b23f7a559bf |
| Source note | uspto-grants-2013_11 |