Dimethylformamide diethylacetal → Ethyl 3-(dimethylamino)-2-(1H-1,2,3-triazol-1-yl)acrylate

Participants

Reaction Conditions

Reaction Steps

44.2 ml (38.0 g, 257.8 mmol) of N,N-dimethylformamide diethyl acetal are added to 20.0 g (128.9 mmol) of the compound from Example 2A, and the mixture is stirred at 100° C. for 16 h. After cooling to RT, the reaction mixture is concentrated under reduced pressure. The residue is triturated with diethyl ether, filtered off and washed with diethyl ether. Yield: 18.0 g (67% of theory)

Provenance & Evidence