HCID 51036479, compound → HCID 51036674, compound

HRID 2039532Notes

Reaction equation

HRID 2039532 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][C:22]=1[O:23]C)[CH2:5][C:6]1[N:15]2[N:16]=[C:17]([NH2:19])[N:18]=[C:14]2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1.COC1C=C(C=C(OC)C=1)CC1N2N=C(N)N=C2C2C=CC=CC=2N=1>>[NH2:19][C:17]1[N:18]=[C:14]2[N:15]([C:6]([CH2:5][C:4]3[CH:20]=[CH:21][C:22]([OH:23])=[C:2]([Br:1])[CH:3]=3)=[N:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=32)[N:16]=1

Participants

3

Reactant 2

HCID 51036479HCID 51036479, compoundHCID 67042932HCID 67042932, compound

Product 1

HCID 51036674HCID 51036674, compoundYield 68%

Procedure

Operating as in Example 39, but employing 5-(3-bromo-4-methoxy-benzyl)-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine, prepared as described in Example 11, instead of 5-(3,5-dimethoxy-benzyl)-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine, the title compound was obtained in 68% yield.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-3efa9fda8c674757995ec4434d148635
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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