Ethanolamine → HCID 51038173, compound

HRID 2039540Notes

Reaction equation

HRID 2039540 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:7]([N:24]=[C:25]([NH2:27])[N:26]=3)[C:8]([CH2:12][C:13]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=4)[NH:15][CH:14]=3)=[N:9][C:10]=2[CH:11]=1.O1C2C=CC(CC3N4N=C(N)N=C4C4C=CC(F)=CC=4N=3)=CC=2OC1.[OH:53][CH2:54][CH2:55][NH2:56]>>[NH2:27][C:25]1[N:26]=[C:6]2[N:7]([C:8]([CH2:12][C:13]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=4)[NH:15][CH:14]=3)=[N:9][C:10]3[CH:11]=[C:2]([NH:56][CH2:55][CH2:54][OH:53])[CH:3]=[CH:4][C:5]=32)[N:24]=1

Participants

4

Reactant 3

HCID 700EthanolamineHCID 51036893HCID 51036893, compoundHCID 51038172HCID 51038172, compound

Product 1

HCID 51038173HCID 51038173, compoundYield 35%

Procedure

Operating as in Example 54, but employing 8-fluoro-5-(5-methoxy-1H-indol-3-ylmethyl)-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine, prepared as described in Example 32, instead of 5-benzo[1,3]dioxol-5-ylmethyl-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine and 2-hydroxy-ethylamine instead of morpholine, the title compound was obtained in 35% yield.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-2db789a194884eb6b373ad3ecf2de241
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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