Ethanolamine → HCID 69927098, compound

HRID 2039541Notes

Reaction equation

F[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:7]([N:25]=[C:26]([NH2:28])[N:27]=3)[C:8]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[C:14]=3[O:23][CH3:24])=[N:9][C:10]=2[CH:11]=1.O1C2C=CC(CC3N4N=C(N)N=C4C4C=CC(F)=CC=4N=3)=CC=2OC1.[OH:54][CH2:55][CH2:56][NH2:57]>>[NH2:28][C:26]1[N:27]=[C:6]2[N:7]([C:8]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[C:14]=3[O:23][CH3:24])=[N:9][C:10]3[CH:11]=[C:2]([NH:57][CH2:56][CH2:55][OH:54])[CH:3]=[CH:4][C:5]=32)[N:25]=1

Participants

Reactant 3

HCID 700Ethanolamine

HCID 51036893HCID 51036893, compound

HCID 67042819HCID 67042819, compound

Product 1

HCID 69927098HCID 69927098, compoundYield 27%

Procedure

Operating as in Example 54, but employing 8-fluoro-5-(2,3,4-trimethoxy-benzyl)-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine prepared as described in Example 33, instead of 5-benzo[1,3]dioxol-5-ylmethyl-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine and 2-hydroxy-ethylamine instead of morpholine, the title compound was obtained in 27% yield.

Workup

customprepared

Sources & evidence

ORD record: ord-585552cc30e445c089108a6524e6e964
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580783B2

Reaction notes

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