Ethanolamine → HCID 51035661, compound

HRID 2039543Notes

Reaction equation

HRID 2039543 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]3[N:20]4[N:21]=[C:22]([NH2:24])[N:23]=[C:19]4[C:18]4[C:17](F)=[CH:16][C:15]([F:26])=[CH:14][C:13]=4[N:12]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.O1C2C=CC(CC3N4N=C(N)N=C4C4C=CC(F)=CC=4N=3)=CC=2OC1.[OH:52][CH2:53][CH2:54][NH2:55]>>[NH2:24][C:22]1[N:23]=[C:19]2[N:20]([C:11]([CH2:10][C:8]3[CH:7]=[CH:6][C:5]4[O:1][CH2:2][O:3][C:4]=4[CH:9]=3)=[N:12][C:13]3[CH:14]=[C:15]([F:26])[CH:16]=[C:17]([NH:55][CH2:54][CH2:53][OH:52])[C:18]=32)[N:21]=1

Participants

4

Reactant 3

HCID 700EthanolamineHCID 51036893HCID 51036893, compoundHCID 51037522HCID 51037522, compound

Product 1

HCID 51035661HCID 51035661, compoundYield 17%

Procedure

Operating as in Example 54, but employing 5-benzo[1,3]dioxol-5-ylmethyl-8,10-difluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine prepared as described in Example 30 instead of 5-benzo[1,3]dioxol-5-ylmethyl-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine and 2-hydroxy-ethylamine instead of morpholine, the title compound was obtained in 17% yield.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-188877404e724cdc897042b4b0e6f807
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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