反应详情

温度

120 °C

To a solution of commercially available benzo[1,3]dioxol-5-yl-acetyl chloride (3.70 g, 18.70 mmol) in anhydrous dichloromethane (20 mL) was added 2-amino-4,6-difluoro-benzoic acid (2.20 g, 12.5 mmol). After the addition of pyridine (5 mL), the mixture was heated under microwave condition at 120° C. for 5 minutes. The solvent was evaporated and the residue was diluted with 2 N HCl solution to induce the precipitation of a brown solid which was filtered, washed with water and dried under vacuum at 50° C., to afford the title compound (3.34 g, 80% yield).

1. customThe solvent was evaporated
2. additionthe residue was diluted with 2 N HCl solution
3. customthe precipitation of a brown solid which
4. filtrationwas filtered
5. washwashed with water
6. customdried under vacuum at 50° C.