HCID 51038409, compound → HCID 51038623, compound

HRID 2039552Notes

Reaction equation

HRID 2039552 reaction equation
C([O:8][C:9]1[CH:33]=[CH:32][C:12]([CH2:13][C:14]2[N:23]3[N:24]=[C:25]([NH2:27])[N:26]=[C:22]3[C:21]3[CH:20]=[CH:19][C:18]([NH:28][CH2:29][CH2:30][OH:31])=[CH:17][C:16]=3[N:15]=2)=[CH:11][C:10]=1[O:34][CH3:35])C1C=CC=CC=1.C(OC1C=CC(CC2N3N=C(N)N=C3C3C=CC(F)=CC=3N=2)=CC=1OC)C1C=CC=CC=1>>[NH2:27][C:25]1[N:26]=[C:22]2[N:23]([C:14]([CH2:13][C:12]3[CH:32]=[CH:33][C:9]([OH:8])=[C:10]([O:34][CH3:35])[CH:11]=3)=[N:15][C:16]3[CH:17]=[C:18]([NH:28][CH2:29][CH2:30][OH:31])[CH:19]=[CH:20][C:21]=32)[N:24]=1

Participants

3

Reactant 2

HCID 51038409HCID 51038409, compoundHCID 51038622HCID 51038622, compound

Product 1

HCID 51038623HCID 51038623, compoundYield 86%

Procedure

Operating as in Example 83, but employing 5-(4-benzyloxy-3-methoxy-benzyl)-8-(2-hydroxy-ethylamino)-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine, prepared as described in Example 67, instead of 5-(4-benzyloxy-3-methoxy-benzyl)-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine, the title compound was obtained in 86% yield.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-17488752b0344ea5a1ff75e64ae703b2
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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