HCID 51038409, compound → HCID 51038838, compound

HRID 2039553Notes

Reaction equation

HRID 2039553 reaction equation
C([O:8][C:9]1[CH:34]=[CH:33][C:12]([CH2:13][C:14]2[N:23]3[N:24]=[C:25]([NH2:27])[N:26]=[C:22]3[C:21]3[CH:20]=[CH:19][C:18]([NH:28][CH2:29][CH2:30][CH2:31][OH:32])=[CH:17][C:16]=3[N:15]=2)=[CH:11][C:10]=1[O:35][CH3:36])C1C=CC=CC=1.C(OC1C=CC(CC2N3N=C(N)N=C3C3C=CC(F)=CC=3N=2)=CC=1OC)C1C=CC=CC=1>>[NH2:27][C:25]1[N:26]=[C:22]2[N:23]([C:14]([CH2:13][C:12]3[CH:33]=[CH:34][C:9]([OH:8])=[C:10]([O:35][CH3:36])[CH:11]=3)=[N:15][C:16]3[CH:17]=[C:18]([NH:28][CH2:29][CH2:30][CH2:31][OH:32])[CH:19]=[CH:20][C:21]=32)[N:24]=1

Participants

3

Reactant 2

HCID 51038409HCID 51038409, compoundHCID 51038621HCID 51038621, compound

Product 1

HCID 51038838HCID 51038838, compoundYield 91%

Procedure

Operating as in Example 83, but employing 5-(4-benzyloxy-3-methoxy-benzyl)-8-(3-hydroxy-propylamino)-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine, prepared as described in Example 66, instead of 5-(4-benzyloxy-3-methoxy-benzyl)-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine, the title compound was obtained in 91% yield.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-5da9c7019bc9432f88172f9b08830f9d
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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