反应详情

To a mixture of 25 mg (52 mmol) of 4-chloro-6-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-7-oxa-2-thia-1,3,5-triaza-cyclopenta[b]naphthalen-8-one in 0.5 ml of THF, is added dropwise 7 ml (77 mmol) of isopropylamine. The reaction is stirred for 18 hours at ambient temperature. Then, the solvent is evaporated and the residue is suspended in a mixture of hexanes and a minimum of EtOAc. After decantation the solid is washed with a minimum of hexanes and after drying 24.5 mg (45 mmol, 87%) of a slightly brown solid were obtained. LC/MS: 544/546 (M+1)+.

1. customThen, the solvent is evaporated
2. additionthe residue is suspended in a mixture of hexanes
3. washAfter decantation the solid is washed with a minimum of hexanes
4. customafter drying 24.5 mg (45 mmol, 87%) of a slightly brown solid
5. customwere obtained