HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanamine → 7-chloro-6-{[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-benzo[1,2,5]thiadiazole-5-carboxylic acid cyclopropylmethyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | 4-chloro-6-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-7-oxa-2-thia-1,3,5-triaza-cyclopenta[b]naphthalen-8-one | HCID 57855908 | — |
| Product | 7-chloro-6-{[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-benzo[1,2,5]thiadiazole-5-carboxylic acid cyclopropylmethyl-amide | HCID 57855947 | — |
Reaction Steps
See step f) of example H2 using 4-chloro-6-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-7-oxa-2-thia-1,3,5-triaza-cyclopenta[b]naphthalen-8-one as starting material and cyclopropanemethylamine. After 18 hours reaction and chromatography column purification, a slightly brown solid is obtained (85%). LC/MS: 556/558 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580785B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d4493aaaa711476d9b350d59fdf3cd27 |
| Source note | uspto-grants-2013_11 |