Ethyl Acetate → HCID 57855960, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1 g (4.35 mmol) of 2,5-diamino-3-chloro-4-methylamino-benzoic acid methyl ester in 153 ml of EtOH, is added 700 mg (6.53 mmol) of formamidine acetate. The mixture is stirred at a temperature of 80° C. for 24 hours. EtOAc is added and the organic phase is washed once with H2O and once with brine. Then the organic layer is dried on Na2SO4, filtrated and concentrated. After purification by flash chromatography on silica gel 0.68 g (2.84 mmol, 65%) of a dark violet solid were obtained. LC/MS: 240/242 (M+1)+.

Provenance & Evidence