反应详情

温度

80 °C

See step e) of example H7 using 2,4,5-triamino-3-chloro-benzoic acid methyl ester as starting material and 2 equivalents of formamidine acetate. The reaction is stirred 2 days at a temperature of 80° C. Then the mixture is extracted with a solution of NaHCO3 saturated (2 times) and EtOAc. The organic phase is washed once with brine, dried on Na2SO4, filtrated and evaporated. A red-violet solid is obtained within 64% yield. LC/MS: 226/228 (M+1)+

1. extractionThen the mixture is extracted with a solution of NaHCO3 saturated (2 times) and EtOAc
2. washThe organic phase is washed once with brine
3. customdried on Na2SO4
4. filtrationfiltrated
5. customevaporated
6. customA red-violet solid is obtained within 64% yield