Isopropylamine → HCID 57855917, compound

Participants

Reaction Steps

See step f) of example H2 with 4-chloro-6-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1H-7-oxa-1,3,5-triaza-cyclopenta[b]naphthalen-8-one as starting material and 2 equivalents of isopropylamine. After overnight stirring at ambient temperature, 2 equivalents of amine were added and the reaction is stopped after 5 hours. After purification by flash chromatography on silica gel, a white solid is obtained in 50% yield. m.p.: 200-203° C.; LC/MS: 526/528 (M+1)+.

Provenance & Evidence